The Emerging Choice for Complex Biologics
Introduction to Dual Chamber Technology
Dual chamber prefilled syringes are an innovative drug delivery system consisting of two separate chambers within a single syringe. One chamber contains the drug component while the other chamber houses buffers, excipients or other constituents required for drug stability and administration. Key advantages of this technology include improved stability of complex biologics, simplified manufacturing and superior user experience.
Drivers for Growing Demand
As biologics become more prevalent in treatment of chronic diseases, there is a need for delivery mechanisms that can effectively handle their complexities. Dual Chamber Prefilled Syringes address some important limitations of single chamber devices while administering biologics. The separated components extend shelf life by preventing drug degradation during storage. It also simplifies filling operations and avoids complexity of lyophilization process required for reconstitution. From usage perspective, it provides one-step, ready-to-inject dosage form and eliminates errors associated with manual reconstitution. Growing biologics market and such compelling value proposition have boosted interest in dual chamber syringes among drug makers.
Product Developments Leveraging Benefits
Recognizing the potential of this innovative delivery system, major pharmaceutical companies are launching new biologics products using dual chamber prefilled syringes. For example, Novo Nordisk recently received FDA approval for its insulin glargine product ABP 980, which comes pre-packaged in a dual chamber syringe. Each syringe contains insulin glargine in one chamber and diluent in another, designed for subcutaneous self-administration in a single step. Similarly, Pfizer launched its biosimilar hypotension drug natalizumab as Tysabri in a dual chamber syringe format for convenient intravenous infusion. With its simple and accurate dosage mechanism, such platforms are expected to drive better patient adherence and compliance to complex therapies.
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